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Invitrogen
CD207 (Langerin) Polyclonal Antibody
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CD207 (Langerin) Antibody (PA5-121010) in WB
Western blot analysis of CD207 (Langerin) in extracts of various cell lines. Samples were incubated with CD207 (Langerin) Polyclonal antibody (Product # PA5-121010) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-121010
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 70-200 of human Langerin/CD207 (NP_0565324)
偶联物
形式
Liquid
浓度
0.52 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: A-549, A-431, Jurkat, Mouse lung, Rat lung, Rat liver. The target is usually found in the following locations: Membrane, Single-pass type II membrane protein.
Immunogen sequence: TISDVKTNVQ LLKGRVDNIS TLDSEIKKNS DGMEAAGVQI QMVNESLGYV RSQFLKLKTS VEKANAQIQI LTRSWEEVST LNAQIPELKS DLEKASALNT KIRALQGSLE NMSKLLKRQN DILQVVSQGW K
靶标信息
Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; CD 207 antigen; CD207; CD207 antigen, langerin; CD207 molecule, langerin; Langerhans cell specific c-type lectin; Langerin
基因别名: CD207; CLEC4K; RGD1565913
UniProt ID: (Human) Q9UJ71, (Mouse) Q8VBX4
Entrez Gene ID: (Human) 50489, (Rat) 502852, (Mouse) 246278
