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Description: The J10MBS monoclonal antibody reacts with human interleukin 17 receptor A (IL-17RA, IL-17R). IL-17RA is a type I membrane protein of approximately 96 kDa (866 amino acids) and is involved in inflammatory responses to IL-17A, IL-17F and IL-17AF heterodimer. It forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling. IL-17RA is ubiquitously expressed, but in leukocytes its expression is elevated on granulocytes and monocytes.
Applications Reported: This J10MBS antibody has been reported for use in flow cytometric analysis.
Applications Tested: This J10MBS antibody has been pre-titrated and tested by flow cytometric analysis of human lysed whole blood. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD217; CDw217; IL-17 receptor A; Interleukin-17 receptor A; MGC10262
基因别名: CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R; IL17RA
UniProt ID: (Human) Q96F46
Entrez Gene ID: (Human) 23765
分子生物学功能: transmembrane signal receptor