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Invitrogen
CD244 Monoclonal Antibody (eBio244F4), FITC
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产品信息
A18348
产品规格
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
eBio244F4
抗原
Mouse CD244.2
偶联物
FITC
FITC
FITC
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
保存条件
4°C, store in dark
运输条件
Wet ice
RRID
靶标信息
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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