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产品信息
MA5-17471
产品规格
种属反应
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
JJ319
抗原
Rat CD28 transfected A20J cells
偶联物
FITC
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 4-5mg/mL BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
RRID
AB_2538861
靶标信息
CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Flow Cytometry
Panel Builder
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
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生物信息学
蛋白别名: CD28; CD28 antigen; MGC138290; sCD28; soluble CD28; T-cell-specific surface glycoprotein CD28; T44
基因别名: Cd28; CD28RNA
UniProt ID: (Rat) P31042
Entrez Gene ID: (Rat) 25660
分子生物学功能:
immunoglobulin receptor superfamily
positive regulation of inflammatory response to antigenic stimulus
immune response
signal transduction
positive regulation of phosphatidylinositol 3-kinase signaling
T cell costimulation
positive regulation of T cell proliferation
T cell activation
negative thymic T cell selection
regulatory T cell differentiation
positive regulation of interleukin-2 biosynthetic process
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
positive regulation of alpha-beta T cell proliferation
positive regulation of isotype switching to IgG isotypes
T cell receptor signaling pathway
positive regulation of protein kinase B signaling
apoptotic signaling pathway
