Invitrogen

CD3/HLA Class 2 Antibody Cocktail, FITC, PE

产品信息

MA5-16958

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Neat

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1/IgG2a

分类

Cocktail

类型

Antibody

克隆号

UCHT1/WR18

抗原

Human infant thymocytes and lymphocytes from a patient with Sezary Syndrome, Human B-CLL cells

偶联物

FITC , PE

形式

Lyophilized

浓度

Conc. Not Determined

纯化类型

purified

保存液

PBS with 1% BSA, 5% sucrose

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

RRID

AB_2538433

产品详细信息

MA5-16958 contains a monoclonal mixture of FITC-conjugated CD3 (clone #UCH-T1, Mouse IgG1) and RPE-conjugated HLA Class 2 (clone #WR18, Mouse IgG2a). UCHT1 recognizes the human CD3 cell surface antigen expressed by T lymphocytes. WR18 recognizes a common determinant on the beta chain of the human HLA Class 2 molecules HLA-DR, DP and DQ. This antigen is expressed on B lymphocytes, monocytes and on activated T lymphocytes. This antibody is designed to permit the simultaneous enumeration of CD3 and HLA Class 2 expressing cells. It is particularly useful in the assessment of HLA Class 2 expression on T lymphocytes.

Reconstitute with 0.5 mL of distilled water. After reconstitution, store product undiluted at 4°C in the dark.

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

靶标信息

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: beta1 domain MHC class II HLA DPB; CD3 antigen, delta subunit; CD3 delta; CD3 epsilon; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD74 antigen; class II HLA beta chain; DHLAG; DW2.2/DR2.2; FLJ18683; HLA class II antigen; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DP14-beta chain; HLA-DP histocompatibility type, beta-1 subunit; HLA-DQ; HLA-DR-gamma; HLA-DRB1; HLADG; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; IA-gamma; lymphocyte antigen; lymphocyte antigen DRB1; major histocompatibility complex class II antigen beta chain; MHC class II antigen; MHC class II antigen beta chain; MHC class II antigen DP beta 1 chain; MHC class II antigen DPB1; MHC class II antigen DPbeta1; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II HLA-DP-beta-1; MHC class II HLA-DQ beta glycoprotein; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRB1; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC DQ beta; MHC HLA DPB1; OKT3, delta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain

基因别名: CD3-DELTA; CD3-GAMMA; CD3D; CD3E; CD3G; CELIAC1; DPB1; DRB1; DRw10; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DQB; HLA-DQB1; HLA-DR1B; HLA-DRB; HLA-DRB1; IDDM1; IMD17; IMD18; IMD19; SS1; T3D; T3E; T3G; TCRE

UniProt ID: (Human) P04234, (Human) P07766, (Human) P09693, (Human) Q30054, (Human) Q31633, (Human) Q4PRC3

Entrez Gene ID: (Human) 915, (Human) 916, (Human) 917, (Human) 3115, (Human) 3119, (Human) 3123

分子生物学功能: major histocompatibility complex protein