This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human CD300E/CMRF35-A5.
CD300e is a member of the glycoprotein family of cell surface proteins expressed on myeloid cells. CD300e interacts with the TYRO protein tyrosine kinase-binding protein and is thought to be involved as an activating receptor. CD300e is expressed on mature myeloid dendritic cells and monocytes, and is down regulated on immature dendritic cells. Further, CD300e interacts with DAP-12, which mediates activating signals. The alloreactive response of naïve T cells has been reported to become enhanced by the activation of CD300e. Diseases associated with CD300e dysfunction include tungiasis and lice infestation.
蛋白别名: CD300 antigen like family member E; CD300 antigen-like family member E; CD300e; CD300e antigen; CLM-2; CMRF35-A5; CMRF35-like molecule 2; Immune receptor expressed on myeloid cells 2; IREM-2; PIgR-2; poly-Ig receptor 2; Polymeric immunoglobulin receptor 2
基因别名: CD300E; CD300LE; CLM-2; CLM2; CMRF35-A5; CMRF35A5; IREM-2; IREM2; PIgR-2; PIgR2
UniProt ID: (Human) Q496F6
Entrez Gene ID: (Human) 342510
分子生物学功能: immunoglobulin receptor superfamily