Invitrogen

CD31 Monoclonal Antibody (SP38)

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CD31 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of CD31 using anti-CD31 Monoclonal Antibody (Product # MA5-16337) in Tonsil Tissue. The recommened dilution for this antibody in immunohistochemistry applications is 1:50.

产品信息

MA5-16337

应用	建议稀释比	已发表文章
免疫组化 (IHC)	-	查看9篇已发表文章 9篇已发表文章
免疫组化（石蜡） (IHC (P))	1:50	-

产品规格
种属反应	Human, Mouse
已发表种属	Mouse, Rat
宿主/亚型	Rabbit / IgG
分类	Monoclonal
类型	Antibody
克隆号	SP38
抗原	Synthetic peptide corresponding to C-terminus of mouse CD31
偶联物	Unconjugated
形式	Liquid
浓度	Conc. Not Determined
保存液	tissue culture supernatant diluted in TBS, pH 7.5, with 1% BSA
内含物	0.1% sodium azide
保存条件	Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID	AB_2537856

产品详细信息

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is tonsil tissue.

靶标信息

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury.

eLife

Niethamer TK,Stabler CT,Leach JP,Zepp JA,Morley MP,Babu A,Zhou S,Morrisey EE

MA5-16337 was used in Immunohistochemistry to identify that different subtypes of endothelial cells exist in capillaries, and that some may be able to perform slightly different jobs during lung recovery.

Mon Feb 24 00:00:00 EST 2020

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.

Cell

Yao M,Ventura PB,Jiang Y,Rodriguez FJ,Wang L,Perry JSA,Yang Y,Wahl K,Crittenden RB,Bennett ML,Qi L,Gong CC,Li XN,Barres BA,Bender TP,Ravichandran KS,Janes KA,Eberhart CG,Zong H

MA5-16337 was used in Immunohistochemistry to reveal an evolutionary process that produces a multi-lateral network within the TME of medulloblastoma: a fraction of tumor cells trans-differentiate into TuAstrocytes, which, in turn, produce IL-4 that stimulates microglia to produce IGF1 to promote tumor progression.

Thu Feb 06 00:00:00 EST 2020

Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Fujimoto M,Tsuneyama K,Fujimoto T,Selmi C,Gershwin ME,Shimada Y

MA5-16337 was used in immunohistochemistry to study the beneficial effects of spirulina on macrophages and metabolic parameters in a murine model of metabolic syndrome

Sat Sep 01 00:00:00 EDT 2012

Hyperglycemia limits experimental aortic aneurysm progression.

Journal of vascular surgery

Miyama N,Dua MM,Yeung JJ,Schultz GM,Asagami T,Sho E,Sho M,Dalman RL

MA5-16337 was used in immunohistochemistry to study the effect of hyperglycemia on the progression of experimental aortic aneurysm

Fri Oct 01 00:00:00 EDT 2010

Eukaryotic expression of extracellular ligand binding domains of murine Tie-2 and its anti-angiogenesis effect in SGC-7901 cell lines.

Journal of gastroenterology and hepatology

Yang H,Yang K,Hu JK,Tang H,Zhang B,Chen ZX,Wang YJ,Chen JP

MA5-16337 was used in immunohistochemistry to study the anti-angiogenic effects on a gastric cancer cell line of the recombinantly expressed extracellular ligand binding domains of murine Tie-2

Mon Feb 01 00:00:00 EST 2010

Correlation between scaffold in vivo biocompatibility and in vitro cell compatibility using mesenchymal and mononuclear cell cultures.

Cell biology and toxicology

Seo YK,Yoon HH,Park YS,Song KY,Lee WS,Park JK

MA5-16337 was used in immunohistochemistry to comapre silk and polyglycolic acid scaffold biocompatibility using mesenchymal and mononuclear cell cultures

Thu Oct 01 00:00:00 EDT 2009

Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma.

Journal of cellular and molecular medicine

Huynh H,Ngo VC,Koong HN,Poon D,Choo SP,Thng CH,Chow P,Ong HS,Chung A,Soo KC

MA5-16337 was used in immunohistochemistry to study the antitumour activity and mechanisms of action of sorafenib against hepatocellular carcinoma xenografts

Sat Aug 01 00:00:00 EDT 2009

Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Huynh H,Ngo VC,Fargnoli J,Ayers M,Soo KC,Koong HN,Thng CH,Ong HS,Chung A,Chow P,Pollock P,Byron S,Tran E

MA5-16337 was used in immunohistochemistry to study the ability of a dual inhibitor of VEGF receptor and FGF receptor tyrosine kinases to inhibit growth in hepatocellular carcinoma

Wed Oct 01 00:00:00 EDT 2008

A central role for hepatocyte growth factor in adipose tissue angiogenesis.

American journal of physiology. Endocrinology and metabolism

Bell LN,Cai L,Johnstone BH,Traktuev DO,March KL,Considine RV

MA5-16337 was used in immunohistochemistry to study adipose tissue angiogenesis and the role of HGF

Fri Feb 01 00:00:00 EST 2008

生物信息学

蛋白别名: CD31; CD31 antigen; EndoCAM; GPIIA'; PECA1; PECAM-1; Platelet endothelial cell adhesion molecule; platelet/endothelial cell adhesion molecule 1

基因别名: C85791; CD31; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; Pecam; PECAM-1; PECAM1

UniProt ID: (Human) P16284, (Mouse) Q08481

Entrez Gene ID: (Human) 5175, (Mouse) 18613

分子生物学功能: immunoglobulin receptor superfamily