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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
流式细胞分析 (Flow) |
Neat | - |
| 产品规格 | |
|---|---|
种属反应 |
Non-human primate, Rat |
宿主/亚型 |
Mouse / IgG1 |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
TLD-3A12 |
抗原 |
Activated, Lewis rat derived microglial cells |
偶联物 |
Biotin
|
形式 |
Liquid |
浓度 |
0.1 mg/mL |
纯化类型 |
Protein A |
保存液 |
PBS with 1% BSA |
内含物 |
0.09% sodium azide |
保存条件 |
4°C or -20°C if preferred |
RRID |
AB_2538425 |
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD31; PECAM-1; Platelet endothelial cell adhesion molecule
基因别名: CD31; Pecam; Pecam1
UniProt ID: (Rat) Q3SWT0
Entrez Gene ID: (Rat) 29583
分子生物学功能:
immunoglobulin receptor superfamily
