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Invitrogen
CD319 (CRACC) Recombinant Rabbit Monoclonal Antibody (5H2L4)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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CD319 (CRACC) Antibody (702905) in WB
Western blot analysis was performed on tissue extracts (30 µg lysate) of Mouse Spleen (Lane 1), Mouse Lung (Lane 2), Mouse Testis (Lane 3), Mouse Thymus (Lane 4) and Mouse Brain (Lane 5). The blot was probed with Anti-CD319 Recombinant Rabbit Monoclonal Antibody (Product # 702905, 1:500 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4,000 dilution). An ~40 kDa band corresponding to CD319 was observed across the tissues test... View More
产品信息
702905
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5H2L4
抗原
Protein corresponding to mouse CD319 [aa246-aa333]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2762402
产品详细信息
This antibody is predicted to react with Monkey, Rat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD319; Leukocyte cell-surface antigen; Novel Ly9; SLAM family member 7
基因别名: 19A; 19A24; 4930560D03Rik; CRACC; CS1; Slamf7
UniProt ID: (Mouse) Q8BHK6
Entrez Gene ID: (Mouse) 75345
