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Invitrogen
CD32a/CD32b/CD32c Recombinant Rabbit Monoclonal Antibody (K01_4P79)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA567576
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4P79
抗原
A synthesized peptide derived from human CD32A + CD32B + CD32C.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD32 denotes Fc gamma receptor II family members that bind the Fc portion of IgG and modulate immune cell activation. CD32a is encoded by FCGR2A and is an activating receptor with an immunoreceptor tyrosine based activation motif that signals through Src family kinases and Syk, expressed on neutrophils, monocytes, macrophages, platelets, and dendritic cells. CD32b is encoded by FCGR2B and is an inhibitory receptor with an immunoreceptor tyrosine based inhibitory motif that recruits SHIP and SHP phosphatases, expressed on B cells, monocytes, macrophages, dendritic cells, and some basophils and mast cells, and it constrains antibody mediated activation to maintain tolerance. CD32c is encoded by FCGR2C and can function as an activating receptor depending on its open reading frame status, with expression largely restricted to natural killer cells and some monocytes, and it contributes to antibody dependent cellular cytotoxicity. Genetic polymorphisms in FCGR2A, FCGR2B, and FCGR2C influence IgG subclass binding, receptor signaling strength, and susceptibility to autoimmune disease, infection outcomes, and responses to therapeutic antibodies. Clinical interest includes using CD32 isoforms as biomarkers and as targets to tune effector functions in antibody therapies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD32; CD32A; CD32B; CD32C; CDw32; Fc-gamma RII-a; Fc-gamma RII-b; Fc-gamma RII-c; Fc-gamma-RIIa; Fc-gamma-RIIb; Fc-gamma-RIIc; FCG2A; FCG2B; FCG2C; FcyRIIA; FcyRIIB; FcyRIIC; IGFR2A; IgG Fc receptor II-a; IgG Fc receptor II-b; IgG Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c
基因别名: CD32; FCG2; FCGR2A; FCGR2A1; FCGR2B; FCGR2C; IGFR2
Entrez Gene ID: (Human) 2212, (Human) 2213, (Human) 9103
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
