Invitrogen

CD38 Monoclonal Antibody (38C03 (SPC32))

Name: CD38 Monoclonal Antibody (38C03 (SPC32))
Brand: Invitrogen
SKU: MA5-14413

高级验证

10 篇参考文献

查看其他133个CD38抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (6)
高级验证 (1)

CD38 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 7

CD38 Antibody (MA5-14413) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with CD38 using peroxidase-conjugate and AEC chromogen. Note membrane staining of lymphocytes.

Product Image Gallery

CD38 Antibody — Antibody specificity was demonstrated by detection of differential basal expression of the target across cell lines tested owing to their inherent genetic constitution. Relative expression of CD138 (Syndecan-1) was observed in Ramos and Daudi which is reported to be positive and not in H1299 and HCT 116 using CD38 Monoclonal Antibody (38C03 (SPC32)) (Product # MA5-14413) in western blot. {RE}

产品信息

MA5-14413

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:50-1:1,000

查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:100

查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

1:2

产品规格

已发表种属

Human, Mouse, Rabbit

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

38C03 (SPC32)

抗原

Recombinant protein encoding the extracellular domain of human CD38

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存条件

4°C

运输条件

Wet ice

AB_10986743

产品详细信息

MA5-14413 targets CD38 in WB, FACS and IHC (P) applications and shows reactivity with Human and Mouse samples. This antibody is not suitable for Jurkat cell lysates or mouse thymus tissues in Western blot analysis.

The MA5-14413 immunogen is recombinant protein encoding the extracellular domain of human CD38.

靶标信息

CD38 is a multifunctional ectoenzyme and type II transmembrane glycoprotein involved in various cellular processes. It catalyzes the conversion of NAD into secondary messengers such as nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic ADP-ribose (cADPR). CD38 plays a crucial role in B cell development, with expression levels fluctuating from high in immature cells to low in intermediate ones, and back to high in mature B cells. It is also present in a variety of tissues and hematopoietic cells, including T cells, NK cells, and monocytes, and is used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38- population is considered to define the most pluripotent hematopoietic stem cells. In addition to its surface expression, CD38 has been identified in the nucleus, where it may regulate calcium levels. It functions as a multi-catalytic ectoenzyme, serving roles as an ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD+ glycohydrolase, or as a cell surface receptor. CD38 is involved in the activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells. It also participates in cell adhesion, signal transduction, and calcium signaling. Antibodies to CD38 are valuable for subtyping lymphomas and leukemias, detecting plasma cells (such as in myelomas), and marking activated B and T cells. CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Dysfunctions in CD38 are associated with diseases like chronic lymphocytic leukemia and Richter's Syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。