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Invitrogen
CD3e Monoclonal Antibody (FN-18), Biotin
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产品信息
APS0309
产品规格
种属反应
Non-human primate,
Rhesus monkey
已发表种属
Non-human primate,
Rhesus monkey
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
FN-18
抗原
Rhesus monkey peripheral blood mononuclear cells.
偶联物
形式
Lyophilized
纯化类型
Ion-exchange chromatography
保存液
PBS with 125mM trehalose, 1% BSA
内含物
no preservative
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitution: Dissolve the contents of the vial by injection of 0.5 mL sterile distilled water.
Stability Lyophilized product is stable for at least one year at 4°C. After reconstitution, the contents can be safely stored at 4°C for one month or for one year at -20°C.
Add 0.02% sodium azide to prevent bacterial growth
靶标信息
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD3 TCR complex; CD3 zeta chain; CD3g molecule, epsilon (CD3-TCR complex); FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor zeta chain; T-cell surface CD3 gamma chain; T3/TCR complex
基因别名: CD3Z; EGK_06950; EGK_06952
Entrez Gene ID: (Rhesus monkey) 697814, (Rhesus monkey) 699582, (Rhesus monkey) 699467, (Rhesus monkey) 705270
