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Proteintech
CD46 Polyclonal Antibody
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产品信息
12494-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CD46 Fusion Protein Ag3131 (38-340 aa encoded by BC030594)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: PPTFEAMEL IGKPKPYYEI GERVDYKCKK GYFYIPPLAT HTICDRNHTW LPVSDDACYR ETCPYIRDPL NGQAVPANGT YEFGYQMHFI CNEGYYLIGE EILYCELKGS VAIWSGKPPI CEKVLCTPPP KIKNGKHTFS EVEVFEYLDA VTYSCDPAPG PDPFSLIGES TIYCGDNSVW SRAAPECKVV KCRFPVVENG KQISGFGKKF YYKATVMFEC DKGFYLDGSD TIVCDSNSTW DPPVPKCLKV STSSTTKSPA SSASGPRPTY KPPVSNYPGY PKPEEGILDS LDVWVIAVIV IAIV (38-340 aa encoded by BC030594)
靶标信息
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; TLX; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
基因别名: AHUS2; CD46; MCP; MIC10; TLX; TRA2.10
UniProt ID: (Human) P15529, (Mouse) O88174
Entrez Gene ID: (Human) 4179, (Mouse) 17221
T cell mediated immunity
proteolysis
single fertilization
regulation of Notch signaling pathway
positive regulation of gene expression
negative regulation of gene expression
interleukin-10 production
positive regulation of interleukin-10 production
sequestering of extracellular ligand from receptor
positive regulation of T cell proliferation
negative regulation of catalytic activity
positive regulation of memory T cell differentiation
positive regulation of regulatory T cell differentiation
negative regulation of complement activation
positive regulation of transforming growth factor beta production
adaptive immune response
complement activation, classical pathway
regulation of complement activation
innate immune response
viral entry into host cell
