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Invitrogen
CD46 Polyclonal Antibody
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CD46 Antibody (PA5-78985) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of CD46 in T-47D cells using CD46 Polyclonal Antibody (Product # PA5-78985). Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and incubated with the primary antibody at 5 µg/mL. DyLight 488 conjugated goat anti-rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-78985
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human CD46 (366-392aa YRYLQRRKKKGTYLTDETHREVKFTSL).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.01mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human K562 whole cell, human A549 whole cell, human A431 whole cell. IHC: human placenta tissue, human prostatic cancer tissue. ICC/IF: T-47D cell .
靶标信息
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antigen identified by monoclonal antibody TRA-2-10; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; measles virus receptor; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen; unnamed protein product
基因别名: AHUS2; MCP; MIC10; TLX; TRA2.10
UniProt ID: (Human) P15529, (Rat) Q9Z0M4, (Mouse) O88174
Entrez Gene ID: (Human) 4179, (Rat) 29333, (Mouse) 17221
T cell mediated immunity
proteolysis
regulation of Notch signaling pathway
positive regulation of interleukin-10 production
positive regulation of T cell proliferation
positive regulation of memory T cell differentiation
positive regulation of regulatory T cell differentiation
positive regulation of proteolysis
negative regulation of complement activation, alternative pathway
negative regulation of complement activation, classical pathway
positive regulation of transforming growth factor beta production
adaptive immune response
regulation of immune response
positive regulation of gene expression
negative regulation of gene expression
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