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CD46 Antibody (PA5-97563) in WB
Western Blot analysis of CD46 using a CD46 Polyclonal antibody (Product # PA5-97563) at a concentration of 3 µg/mL. Positive WB detected in: Hela whole cell lysate, Mouse liver tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:50,000 dilution. Observed band size: 44 kDa.
Product Details
PA5-97563
Applications
Tested Dilution
Publications
产品规格
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Recombinant Human Membrane cofactor protein (164-325AA)
Conjugate
Unconjugated
形式
Liquid
浓度
1.75 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
RRID
AB_2812179
Target Information
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; TLX; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
Gene Aliases: AHUS2; CD46; MCP; MIC10; TLX; TRA2.10
UniProt ID: (Human) P15529, (Mouse) O88174
Entrez Gene ID: (Human) 4179, (Mouse) 17221
T cell mediated immunity
proteolysis
single fertilization
regulation of Notch signaling pathway
positive regulation of gene expression
negative regulation of gene expression
interleukin-10 production
positive regulation of interleukin-10 production
sequestering of extracellular ligand from receptor
positive regulation of T cell proliferation
negative regulation of catalytic activity
positive regulation of memory T cell differentiation
positive regulation of regulatory T cell differentiation
negative regulation of complement activation
positive regulation of transforming growth factor beta production
adaptive immune response
complement activation, classical pathway
regulation of complement activation
innate immune response
viral entry into host cell
Performance Guarantee
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