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Invitrogen
CD47 Monoclonal Antibody (MEM-122), FITC
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产品信息
A15734
产品规格
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
MEM-122
抗原
Native purified CD47 from African Green Monkey COS-7 cells
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
CD47, known as integrin-associated protein (IAP), is a glycosylated transmembrane glycoprotein with five domains, expressed widely across hematopoietic cells like T and B cells, monocytes, platelets, and erythrocytes, as well as non-hematopoietic cells. It interacts with integrins such as CD51/CD61 and CD41/CD61, and serves as a receptor for thrombospondin, mediating bi-directional signaling that affects neural synaptic activity and macrophage phagocytosis. CD47 acts as a ligand for CD172a (SIRP alpha), an inhibitory receptor on macrophages, preventing phagocytosis of CD47-positive cells. This interaction influences cell migration, B cell adhesion, T cell activation, and neuronal development, particularly in synapse-rich brain and retina regions. It also modulates chondrocyte responses to mechanical signals. T cell expression of CD47 can lead to activation or apoptosis in the presence of thrombospondin. Monoclonal antibody stimulation of CD47 has been shown to induce CD4+CD25- suppressive activity and increase Foxp3 expression. CD47's role in membrane transport, signal transduction, and its broad tissue distribution highlight its significance in various physiological processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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