Leinco Technologies

CD49d Monoclonal Antibody (PS/2), Functional Grade, In Vivo GOLD™

Name: CD49d Monoclonal Antibody (PS\/2), Functional Grade, In Vivo GOLD\u2122
Brand: Leinco Technologies
SKU: C797-100MG

查看其他53个CD49d (Integrin alpha 4)抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image CD49d Monoclonal Antibody (PS/2), Functional Grade, In Vivo GOLD™

产品信息

C797-100MG

应用

建议稀释比

已发表文章

免疫组化 (IHC)

Assay-dependent

流式细胞分析 (Flow)

Assay-dependent

免疫沉淀 (IP)

Assay-dependent

功能检测 (Functional)

Assay-dependent

产品规格

种属反应

Human, Mouse

宿主/亚型

Rat / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

PS/2

抗原

P815 DBA/2 murine mastocytoma cells.

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偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

≥5.0 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.2-7.4

内含物

no preservative

保存条件

4°C short term, -80°C long term

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Specificity: PS/2 activity is directed against mouse CD49d and is cross reactive against human CD49d.

Endotoxin Level: <1.0 EU/µg as determined by the LAL method.

Purity: ≥95% monomer by analytical SEC and >95% by SDS Page.

Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -70C. Avoid Repeated Freeze Thaw Cycles.

靶标信息

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49d; Integrin alpha-4; Integrin alpha-IV; integrin alpha4B; ITGA-IV; LPAM subunit alpha; Lymphocyte Peyer patch adhesion molecules subunit alpha; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha

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基因别名: CD49D; IA4; ITGA4; Itga4B

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UniProt ID: (Human) P13612, (Mouse) Q00651

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Entrez Gene ID: (Human) 3676, (Mouse) 16401

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功能

fibronectin binding protein binding coreceptor activity C-X3-C chemokine binding metal ion binding cell adhesion molecule binding protein antigen binding integrin

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