FIGURE: 1 / 3
Immunogen sequence: TVPHLRDTKK TIQFDFQILS KNLNNSQSDV VSFRLSVEAQ AQVTLNGVSK PEAVLFPVSD WHPRDQPQKE EDLGPAVHHV YELINQGPSS ISQGVLELSC PQALEGQQLL YVTRVTGLNC TTNHPINPKG LELDPEGSLH HQQKREAPSR SSASSGPQIL KCPEAECFRL RCELGPLHQQ ESQSLQLHFR VWAKTFLQRE HQPFSLQCEA VYKALKMPYR ILPRQLPQKE RQVATAVQWT KAEGSYGVPL W; Positive Samples: A-549, NIH/3T3, HT-1080, Rat heart, Mouse heart; Cellular Location: Membrane, Single-pass type I membrane protein
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Protein Aliases: CD49 antigen-like family member E; CD49e; fibronectin receptor alpha polypeptide; Fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; integrin alpha 5; integrin alpha 5 (fibronectin receptor alpha); Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); very late activation protein 5, alpha subunit; VLA-5
Gene Aliases: CD49e; FNRA; ITGA5; Itga5_retired; VLA-5; VLA5; VLA5A
Molecular Function: integrin