Invitrogen

CD49f (Integrin alpha 6) Monoclonal Antibody (eBioGoH3 (GoH3)), PE-Cyanine7, eBioscience™

CD49f (Integrin alpha 6) Antibody in Flow Cytometry (Flow)

图: 1 / 50

CD49f (Integrin alpha 6) Antibody (25-0495-82) in Flow

Staining of normal human peripheral blood cells with 0.25 µg of Rat IgG2a K Isotype Control PE-Cyanine7 (Product # 25-4321-82) (blue histogram) or 0.25 µg of Anti-Human/Mouse CD49f (Integrin alpha 6) PE-Cyanine7 (purple histogram). Cells in the lymphocyte gate were used for analysis.

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产品信息

25-0495-82

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.5 µg/test

查看48篇已发表文章 48篇已发表文章

产品规格

种属反应

Human, Mouse

已发表种属

Human, Mouse

宿主/亚型

Rat / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

eBioGoH3 (GoH3)

偶联物

PE-Cyanine7 PE-Cyanine7 PE-Cyanine7

激发/发射光谱

569/780 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10804881

产品详细信息

Description: The eBioGoH3 monoclonal antibody reacts with mouse and human CD49f, also known as integrin alpha 6, very late activation antigen 6 (VLA-6 alpha chain), and platelet gpIc. CD49f is a 120 kD transmembrane protein. CD49f associates with CD29, the integrin beta 1 chain, to form the VLA-6 complex; CD49f also associates with CD104, the integrin beta 4 chain, to form the alpha 6 beta 4 complex. CD49f is expressed primarily on T cells, monocytes, platelets, epithelial and endothelial cells. CD49f expression has also been found on germinal center B cells. The eBioGoH3 antibody is cross-reactive to integrin alpha 6 on human, mouse and bovine cells. This antibody has also been reported to have functional activity in blocking the binding of integrin alpha 6 to laminin.

Applications Reported: This eBioGoH3 (GoH3) antibody has been reported for use in flow cytometric analysis.

Applications Tested: This eBioGoH3 (GoH3) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis.

Cell reports

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The Effect of Infant Gastric Digestion on Human Maternal Milk Cells.

Molecular nutrition & food research

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ROR2 regulates self-renewal and maintenance of hair follicle stem cells.

Nature communications

Veltri A,Lang CMR,Cangiotti G,Chan CK,Lien WH

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Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.

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Thu Jul 08 00:00:00 EDT 2021

CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.

Neoplasia (New York, N.Y.)

Feng D,Yan K,Liang H,Liang J,Wang W,Yu H,Zhou Y,Zhao W,Dong Z,Ling B

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Fri Jan 01 00:00:00 EST 2021

GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization.

JCI insight

Kashgari G,Venkatesh S,Refuerzo S,Pham B,Bayat A,Klein RH,Ramos R,Ta AP,Plikus MV,Wang PH,Andersen B

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Wed Sep 08 00:00:00 EDT 2021

Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions.

Science advances

Abu El Maaty MA,Grelet E,Keime C,Rerra AI,Gantzer J,Emprou C,Terzic J,Lutzing R,Bornert JM,Laverny G,Metzger D

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone.

The EMBO journal

Wu J,Tian WJ,Liu Y,Wang HJ,Zheng J,Wang X,Pan H,Li J,Luo J,Yang X,Lau LF,Ghashghaei HT,Shen Q

25-0495 was used in Flow cytometry/Cell sorting to show that ependyma-derived matricellular protein CCN1 (cellular communication network factor 1) negatively regulates niche capacity and NSC number in the adult ventricular-subventricular zone (V-SVZ).

Mon Mar 02 00:00:00 EST 2020

An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration.

Molecular biology of the cell

Su S,Begum S,Ezratty EJ

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Sat Aug 01 00:00:00 EDT 2020

Chronic expression of p16^INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation.

Nature communications

Azazmeh N,Assouline B,Winter E,Ruppo S,Nevo Y,Maly A,Meir K,Witkiewicz AK,Cohen J,Rizou SV,Pikarsky E,Luxenburg C,Gorgoulis VG,Ben-Porath I

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Mon Jun 01 00:00:00 EDT 2020

Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.

International journal of molecular sciences

Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J

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Wed Jan 08 00:00:00 EST 2020

Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Tang C,Span PN,Rowan AE,Aalders TW,Schalken JA,Adema GJ,Kouwer PHJ,Zegers MMP,Ansems M

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Tue Sep 01 00:00:00 EDT 2020

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.

Nature communications

Riedel R,Addo R,Ferreira-Gomes M,Heinz GA,Heinrich F,Kummer J,Greiff V,Schulz D,Klaeden C,Cornelis R,Menzel U,Kröger S,Stervbo U,Köhler R,Haftmann C,Kühnel S,Lehmann K,Maschmeyer P,McGrath M,Naundorf S,Hahne S,Sercan-Alp Ö,Siracusa F,Stefanowski J,Weber M,Westendorf K,Zimmermann J,Hauser AE,Reddy ST,Durek P,Chang HD,Mashreghi MF,Radbruch A

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Fri May 22 00:00:00 EDT 2020

Integrated Single-Cell Transcriptomics and Chromatin Accessibility Analysis Reveals Regulators of Mammary Epithelial Cell Identity.

Cell reports

Pervolarakis N,Nguyen QH,Williams J,Gong Y,Gutierrez G,Sun P,Jhutty D,Zheng GXY,Nemec CM,Dai X,Watanabe K,Kessenbrock K

25-0495-82 was used in Flow Cytometry to provide a resource to reveal cis/trans-regulatory elements associated with MEC identity and differentiation that will serve as a reference to determine how the chromatin accessibility landscape changes during breast cancer.

Tue Oct 20 00:00:00 EDT 2020

Phenotype changes of oral epithelial stem cells after in vitro culture.

Brazilian oral research

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25-0495 was used in Flow cytometry/Cell sorting to suggest that phenotype changes may be part of an intrinsic cellular mechanism to conserve levels of protein expression as they may found in the human body.

Thu Apr 23 00:00:00 EDT 2020

m6A RNA methylation impacts fate choices during skin morphogenesis.

eLife

Xi L,Carroll T,Matos I,Luo JD,Polak L,Pasolli HA,Jaffrey SR,Fuchs E

25-0495 was used in Flow cytometry/Cell sorting to study mouse skin embryogenesis to tackle m6A's functions and physiological importance.

Wed Aug 26 00:00:00 EDT 2020

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.

Disease models & mechanisms

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A basal-enriched microRNA is required for prostate tumorigenesis in a Pten knockout mouse model.

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Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer.

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Tue Sep 29 00:00:00 EDT 2020

Integrin-Rac signalling for mammary epithelial stem cell self-renewal.

Breast cancer research : BCR

Olabi S,Ucar A,Brennan K,Streuli CH

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Mon Oct 22 00:00:00 EDT 2018

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Breast cancer research : BCR

Kim H,Lin Q,Glazer PM,Yun Z

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Tue Mar 06 00:00:00 EST 2018

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Breast cancer research : BCR

Kim H,Lin Q,Glazer PM,Yun Z

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Tue Mar 06 00:00:00 EST 2018

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.

Nature communications

Nguyen QH,Pervolarakis N,Blake K,Ma D,Davis RT,James N,Phung AT,Willey E,Kumar R,Jabart E,Driver I,Rock J,Goga A,Khan SA,Lawson DA,Werb Z,Kessenbrock K

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Wed May 23 00:00:00 EDT 2018

Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.

Cell reports

Barros-Silva JD,Linn DE,Steiner I,Guo G,Ali A,Pakula H,Ashton G,Peset I,Brown M,Clarke NW,Bronson RT,Yuan GC,Orkin SH,Li Z,Baena E

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Tue Dec 18 00:00:00 EST 2018

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage.

Nature

Naik S,Larsen SB,Gomez NC,Alaverdyan K,Sendoel A,Yuan S,Polak L,Kulukian A,Chai S,Fuchs E

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Thu Oct 26 00:00:00 EDT 2017

Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Cell host & microbe

Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y

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Wed Apr 12 00:00:00 EDT 2017

Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny.

The EMBO journal

Chacón-Martínez CA,Klose M,Niemann C,Glauche I,Wickström SA

25-0495 was used in Flow cytometry/Cell sorting to uncovers regulatory dynamics by which phenotypic plasticity of cells drives population-level homeostasis within a niche, and provides a discovery tool for studies on adult stem cell fate.

Tue Jan 17 00:00:00 EST 2017

Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway.

PLoS biology

Weeden CE,Chen Y,Ma SB,Hu Y,Ramm G,Sutherland KD,Smyth GK,Asselin-Labat ML

25-0495 was used in Flow cytometry/Cell sorting to study the cellular origins and molecular processes contributing to lung squamous cell carcinoma.

Sun Jan 01 00:00:00 EST 2017

Low Testosterone Alters the Activity of Mouse Prostate Stem Cells.

The Prostate

Zhou Y,Copeland B,Otto-Duessel M,He M,Markel S,Synold TW,Jones JO

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Sat Apr 01 00:00:00 EDT 2017

Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.

Nature communications

Tao L,Xiang D,Xie Y,Bronson RT,Li Z

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Mon Feb 13 00:00:00 EST 2017

Characterization of the CD49f+/CD44+/CD24- single-cell derived stem cell population in basal-like DCIS cells.

Oncotarget

Duru N,Gernapudi R,Lo PK,Yao Y,Wolfson B,Zhang Y,Zhou Q

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Tue Jul 26 00:00:00 EDT 2016

Inhibition of the glucocorticoid receptor results in an enhanced miR-99a/100-mediated radiation response in stem-like cells from human prostate cancers.

Oncotarget

Rane JK,Erb HH,Nappo G,Mann VM,Simms MS,Collins AT,Visakorpi T,Maitland NJ

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Tue Aug 09 00:00:00 EDT 2016

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.

Nature communications

Yosef R,Pilpel N,Tokarsky-Amiel R,Biran A,Ovadya Y,Cohen S,Vadai E,Dassa L,Shahar E,Condiotti R,Ben-Porath I,Krizhanovsky V

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Wed Apr 06 00:00:00 EDT 2016

Yap1 promotes the survival and self-renewal of breast tumor initiating cells via inhibiting Smad3 signaling.

Oncotarget

Sun JG,Chen XW,Zhang LP,Wang J,Diehn M

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.

Oncotarget

Greenwood E,Maisel S,Ebertz D,Russ A,Pandey R,Schroeder J

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Tue Sep 20 00:00:00 EDT 2016

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Cell death and differentiation

Aghababaei M,Hogg K,Perdu S,Robinson WP,Beristain AG

25-0495 was used in Flow cytometry/Cell sorting to identify E-cadherin as a novel A Disintegrin and Metalloproteinase 12 (ADAM12) substrate.

Tue Dec 01 00:00:00 EST 2015

The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion.

The Journal of biological chemistry

Shahi P,Slorach EM,Wang CY,Chou J,Lu A,Ruderisch A,Werb Z

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Fri Feb 06 00:00:00 EST 2015

Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation.

PloS one

Zoch A,Mayerl S,Schulz A,Greither T,Frappart L,Rübsam J,Heuer H,Giovannini M,Morrison H

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Mon May 23 00:00:00 EDT 2016

In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.

Nature cell biology

Lien WH,Polak L,Lin M,Lay K,Zheng D,Fuchs E

25-0495 was used in Flow cytometry/Cell sorting to show that during hair follicle stem cell quiescence, TCF3, TCF4 and TLE bind coordinately and repress Wnt target genes.

Sat Feb 01 00:00:00 EST 2014

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

Cancer research

Kottakis F,Foltopoulou P,Sanidas I,Keller P,Wronski A,Dake BT,Ezell SA,Shen Z,Naber SP,Hinds PW,McNiel E,Kuperwasser C,Tsichlis PN

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Tue Jul 15 00:00:00 EDT 2014

FGF ligands of the postnatal mammary stroma regulate distinct aspects of epithelial morphogenesis.

Development (Cambridge, England)

Zhang X,Martinez D,Koledova Z,Qiao G,Streuli CH,Lu P

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Nature cell biology

Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Breast cancer research : BCR

Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Mon Dec 08 00:00:00 EST 2014

Generation of a novel germline stem cell line expressing a germline-specific reporter in the mouse.

Genesis (New York, N.Y. : 2000)

Shiura H,Ikeda R,Lee J,Sato T,Ogonuki N,Hirose M,Ogura A,Ogawa T,Abe K

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2013

Distinct effects of EGFR ligands on human mammary epithelial cell differentiation.

PloS one

Mukhopadhyay C,Zhao X,Maroni D,Band V,Naramura M

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Fri Jul 11 00:00:00 EDT 2014

Highly upregulated Lhx2 in the Foxn1-/- nude mouse phenotype reflects a dysregulated and expanded epidermal stem cell niche.

PloS one

Bohr S,Patel SJ,Vasko R,Shen K,Huang G,Yarmush ML,Berthiaume F

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Mon Dec 23 00:00:00 EST 2013

Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.

Stem cells (Dayton, Ohio)

Paik DY,Janzen DM,Schafenacker AM,Velasco VS,Shung MS,Cheng D,Huang J,Witte ON,Memarzadeh S

Published figure using CD49f (Integrin alpha 6) monoclonal antibody (Product # 25-0495-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2012

生物信息学

蛋白别名: CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; integrin alpha 6; Integrin alpha-6; integrin alpha6B; integrin, alpha 6; VLA-6

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基因别名: 5033401O05Rik; AI115430; CD49f; ITGA6; ITGA6B; VLA-6

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UniProt ID: (Human) P23229, (Mouse) Q61739

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Entrez Gene ID: (Human) 3655, (Mouse) 16403

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功能

integrin binding protein binding insulin-like growth factor I binding neuregulin binding metal ion binding cadherin binding involved in cell-cell adhesion protein complex binding laminin binding integrin

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