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Invitrogen
CD50 (ICAM-3) Monoclonal Antibody (CBR-IC3/1), Biotin, eBioscience™
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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CD50 (ICAM-3) Antibody (BMS111BT) in Flow
Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD41 FITC and CD50 Biotin followed by APC conjugated streptavidin. As expected based on known relative expression patterns, CD50 clone CBR-IC3/1 stains lymphocytes (pink), monocytes (orange), granulocytes (blue) and a small subset of CD45 negative cells (green).
产品信息
BMS111BT
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CBR-IC3/1
偶联物
Biotin
形式
Liquid
浓度
10 µL/Test
纯化类型
Affinity chromatography
保存液
TBS, pH 7.2-7.4, with 1% BSA
内含物
0.02% sodium azide
保存条件
2-8°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10596497
产品详细信息
Description: Intercellular Adhesion Molecule-3 (ICAM-3) is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). ICAM-3 is a heavily glycosylated, integral membrane protein with five immunoglobulin-like domains. It shares high homology to ICAM-1 and ICAM-2 in the extracellular region. In contrast to ICAM-1 and ICAM-2, ICAM-3 is absent on endothelia. ICAM-3 is expressed on resting lymphocytes, monocytes and neutrophils, representing the major LFA-1 ligand on these cells. The finding that adhesion of resting T lymphocytes to LFA-1 occurs primarily via ICAM-3 combined with the fact that ICAM-3 is much better expressed than other LFA-1 ligands on monocytes and resting lymphocytes implies an important role for ICAM-3 in the initiation of immune responses.
Applications Tested: Flow Cytometry.
Purity: >95%.
靶标信息
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD50; CDw50; ICAM-3; ICAM-R; Intercellular adhesion molecule 3; intercellular adhesion molecule-3
基因别名: CD50; CDW50; ICAM-R; ICAM3
UniProt ID: (Human) P32942
Entrez Gene ID: (Human) 3385
