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Proteintech
CD71 Polyclonal Antibody
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产品信息
32333-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CD71 fusion protein Eg1064
偶联物
形式
Liquid
浓度
500 µg/mL
规格
75 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Sequence of this protein is as follows: CKRVEQKEEC VKLAETEETD KSETMETEDV PTSSRLYWAD LKTLLSEKLN SIEFADTIKQ LSQNTYTPRE AGSQKDESLA YYIENQFHEF KFSKVWRDEH YVKIQVKSSI GQNMVTIVQS NGNLDPVESP EGYVAFSKPT EVSGKLVHAN FGTKKDFEEL SYSVNGSLVI VRAGEITFAE KVANAQSFNA IGVLIYMDKN KFPVVEADLA LFGHAHLGTG DPYTPGFPSF NHTQFPPSQS SGLPNIPVQT ISRAAAEKLF GKMEGSCPAR WNIDSSCKLE LSQNQNVKLI VKNVLKERRI LNIFGVIKGY EEPDRYVVVG AQRDALGAGV AAKSSVGTGL LLKLAQVFSD MISKDGFRPS RSIIFASWTA GDFGAVGATE WLEGYLSSLH LKAFTYINLD KVVLGTSNFK VSASPLLYTL MGKIMQDVKH PVDGKSLYRD SNWISKVEKL SFDNAAYPFL AYSGIPAVSF CFCEDADYPY LGTRLDTYEA LTQKVPQLNQ MVRTAAEVAG QLIIKLTHDV ELNLDYEMYN SKLLSFMKDL NQFKTDIRDM GLSLQWLYSA RGDYFRATSR LTTDFHNAEK TNRFVMREIN DRIMKVEYHF LSPYVSPRES PFRHIFWGSG SHTLSALVEN LKLRQKNITA FNETLFRNQL ALATWTIQGV ANALSGDIWN IDNEF
靶标信息
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD antigen CD71; CD71; mammary tumor virus receptor 1; p90; T9; TR; transferrin receptor; Transferrin receptor 1; Transferrin receptor protein 1; unnamed protein product
基因别名: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; IMD46; Mtvr-1; Mtvr1; p90; T9; TFR; TFR1; TFRC; TR; TRFR
UniProt ID: (Human) Q1HE24, (Mouse) Q62351
Entrez Gene ID: (Human) 7037, (Mouse) 22042
virus receptor activity
RNA binding
double-stranded RNA binding
transferrin receptor activity
protein binding
protein kinase binding
Hsp70 protein binding
identical protein binding
protein homodimerization activity
macromolecular complex binding
chaperone binding
glycoprotein binding
iron ion transmembrane transporter activity
transferrin transmembrane transporter activity
poly(A) RNA binding
metalloprotease
regulation of cell growth
response to hypoxia
iron ion transport
cellular iron ion homeostasis
endocytosis
receptor-mediated endocytosis
acute-phase response
signal transduction
cell surface receptor signaling pathway
response to nutrient
response to iron ion
response to manganese ion
positive regulation of gene expression
negative regulation of mitochondrial fusion
osteoclast differentiation
positive regulation of B cell proliferation
positive regulation of protein complex assembly
receptor internalization
response to retinoic acid
transferrin transport
intracellular signal transduction
positive regulation of T cell proliferation
regulation of cell proliferation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of isotype switching
response to copper ion
viral entry into host cell
multicellular organismal iron ion homeostasis
cellular response to xenobiotic stimulus
regulation of postsynaptic membrane neurotransmitter receptor levels
transport across blood-brain barrier
positive regulation of protein localization to nucleus
cellular response to leukemia inhibitory factor
iron ion transmembrane transport
cellular response to drug
positive regulation of bone resorption
protein transmembrane transport
iron ion import
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