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产品信息
MMCD72104
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
10.1.D2
抗原
Mouse CD72.1 (Lyb-2.1). from DBA/2 mouse spleen cells
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
purified
保存液
PBS, pH 7.5
内含物
<0.1% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Wet ice (domestic); Wet or Dry ice (international)
RRID
AB_2539791
靶标信息
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-cell differentiation antigen CD72; CD72; Ly-32; Lyb-2; Lymphocyte antigen 32; RP11-331F9.9
基因别名: Cd72; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2
UniProt ID: (Mouse) P21855
Entrez Gene ID: (Mouse) 12517
