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Invitrogen
CD73 Monoclonal Antibody (AD2), Alexa Fluor™ 647
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CD73 Antibody (MA562343) in Flow
Flow cytometry (surface staining) of CD73 in human peripheral whole blood. Samples were stained with CD73 monoclonal antibody (Product # MA562343) using a dilution of 4 µL reagent/100 µL of peripheral whole blood. Separation of CD73 positive CD19 positive B cells (red-filled) from CD73 negative CD3 negative lymphocytes (black-dashed).
产品信息
MA562343
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
AD2
抗原
Pre-B leukemia cells.
偶联物
激发/发射光谱
650/671 nm
查看光谱
形式
Liquid
浓度
0.04 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD73, also known as Ecto-5-prime-nucleotidase or 5-prime-ribonucleotide phosphohydrolase, is an enzyme that catalyzes the conversion of purine 5-prime mononucleotides to nucleosides at neutral pH, with AMP as its preferred substrate. It is composed of a dimer of two identical 70 kDa subunits, externally bound to the plasma membrane via a glycosyl phosphatidyl inositol linkage. CD73 serves as a marker of lymphocyte differentiation and is expressed on a subset of lymphocytes, increasing during lymphocyte maturation. It is found on memory CD4 T cells, which resemble uncommitted primed precursor helper cells (Thpp) capable of differentiating into Th1 or Th2 cells, and is also present on regulatory T cells. CD73 deficiency is associated with various immunodeficiency diseases. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes, distinguishable from CD73 by their substrate affinities, requirement for divalent magnesium ions, activation by ATP, and inhibition by inorganic phosphate. The CD73 gene is localized to chromosome 6q14-q21, and defects in this gene can lead to conditions such as calcification of joints and arteries, and intestinal tuberculosis. Additionally, two transcript variants encoding different isoforms of CD73 have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5'-deoxynucleotidase; 5'-NT; 5'-nucleotidase; 5'-nucleotidase, ecto (CD73); CD73; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Purine 5-Prime-Nucleotidase; Thymidylate 5'-phosphatase
基因别名: CALJA; CD73; E5NT; eN; eNT; NT; NT5; NT5E; NTE
UniProt ID: (Human) P21589
Entrez Gene ID: (Human) 4907
purine nucleotide biosynthetic process
purine nucleotide catabolic process
AMP catabolic process
DNA metabolic process
leukocyte cell-cell adhesion
brain development
response to aluminum ion
dephosphorylation
adenosine biosynthetic process
pyrimidine nucleoside catabolic process
positive regulation of lipid biosynthetic process
negative regulation of inflammatory response
