This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human CD8B/P37/LEU2.
The CD8B antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
蛋白别名: CD8; CD8 antigen, beta polypeptide 1 (p37); CD8alpha; CD8b; CD8beta; Leu-2; MAL; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain
基因别名: CD8B; CD8B1; LEU2; LY3; LYT3; P37
UniProt ID: (Human) P10966
Entrez Gene ID: (Human) 926