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Invitrogen
CD98 Monoclonal Antibody (RL388), PE, eBioscience™
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CD98 Antibody (12-0981-81) in Flow
Staining of mouse splenocytes with Rat IgG2a kappa Isotype Control FITC (Product # 11-4321-42) (left, open histogram) or Rat IgG2a kappa Isotype Control PE (Product # 12-4321-80) (right, open histogram) and Anti-Mouse CD98 FITC (left, filled histogram) and 0.25 µg of Anti-Mouse CD98 PE (right, filled histogram). Total viable cells were used for analysis.
产品信息
12-0981-81
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
C. elegans,
Mouse,
Rat
宿主/亚型
Rat
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
RL388
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: The RL388 monoclonal antibody reacts with mouse CD98, also known as 4F2 antigen and Ly-10. RL388 detects a disulfide-linked heterodimer complex (130 kDa) composed of a glycosylated heavy (86 kDa) and a nonglycosylated light (39 kDa) subunits. CD98 is expressed on the surface of activated lymphocytes and is involved in cell activation and calcium flux events.
Applications Reported: The RL388 antibody has been reported for use in flow cytometric analysis.
Applications Tested: The RL388 antibody has been tested by flow cytometric analysis of activated and resting mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
生物信息学
蛋白别名: 4F2 cell-surface antigen heavy chain; 4F2hc; Amino acid transporter heavy chain SLC3A2; antigen identified by monoclonal antibodies 4F2; CD98; CD98 antigen; CD98 heavy chain; Solute carrier family 3 member 2; type II transmembrane protein
基因别名: 4F2; 4F2HC; AI314110; Cd98; Ly-10; Ly-m10; Ly10; Mdu1; Mgp-2hc; NACAE; Slc3a2
UniProt ID: (Mouse) P10852
Entrez Gene ID: (Mouse) 17254
