Invitrogen

CDCP1 Polyclonal Antibody

Product Image Gallery

CDCP1 Antibody in Western Blot (WB) — Western blot analysis of CDCP1 in extracts from PC3 cells using CDCP1 polyclonal antibody (Product # PA5-17245).

CDCP1 Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P)) — Figure 7 Genetic alterations in CDCP1 in human primary TNBCs ( A ) Physical map of 3p21.31 region (spanning CDCP1 ), including genomic clones selected for FISH experiments covering the CDCP1 locus, their size in Kb, and the genes that they encompass. Maps are derived from University of California Santa Cruz Genome Browser ( http://genome.ucsc.edu/ ), with adaptations. ( B ) Representative images of dual-color FISH using CDCP1 /CEP3 probes on FFPE human primary TNBC specimens, showing tumor cells with: > 3 red signals for CEP3 and > 3 green signals for the CDCP1 locus (polysomy); < 3 signals for CEP3 and > 3 green signals for CDCP1 (amplification); < 3 signals for CEP3 and < 3 green signals for CDCP1 (disomy); and > 3 signals for CEP3 and < 3 green signals for the CDCP1 locus (deletion). ( C ) Correlation analysis between percentage of FISH-positive cells with percentage of IHC-positive cells ( n = 75; p < 0.0001; Pearson r = 0.6121; 95% confidence interval 0.4472 to 0.7367).

CDCP1 Antibody in Immunohistochemistry (IHC) — Fig. 6 Genetic alterations of CDCP1 in TNBC. FFPE sections of TNBC specimens were analyzed by dual-color FISH using for CDCP1 genetic alteration CDCP1/CEP3 probes on a FFPE sections of TNBC specimens FISH. a Representative image of TNBC specimen positive for CDCP1 IHC staining, showing tumor cells with > 3 red signals for CEP3 and > 3 green signals for the CDCP1 locus (polysomy); b Representative image of TNBC specimen negative for CDCP1 IHC staining, showing tumor cells with > 3 signals for CEP3 and < 3 green signals for the CDCP1 locus (deletion)

产品信息

PA5-17245

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:1,000	-
免疫组化 (IHC)	-	查看2篇已发表文章 2篇已发表文章
免疫组化（石蜡） (IHC (P))	-	查看1篇已发表文章 1篇已发表文章
免疫细胞化学 (ICC/IF)	-	查看1篇已发表文章 1篇已发表文章
免疫沉淀 (IP)	1:100	-

产品规格
种属反应	Human
已发表种属	Human
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to amino acids near the carboxy-terminus of human CDCP1
偶联物	Unconjugated
形式	Liquid
纯化类型	Antigen affinity chromatography
保存液	0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物	no preservative
保存条件	-20°C
RRID	AB_10979963

产品详细信息

It is not recommended to aliquot this antibody.

靶标信息

CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. CDCP1 is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The PDGFRβ/ERK1/2 pathway regulates CDCP1 expression in triple-negative breast cancer.

BMC cancer

Forte L,Turdo F,Ghirelli C,Aiello P,Casalini P,Iorio MV,D'Ippolito E,Gasparini P,Agresti R,Belmonte B,Sozzi G,Sfondrini L,Tagliabue E,Campiglio M,Bianchi F

PA5-17245 was used in Immunohistochemistry to study the mechanisms driving CDCP1 over-expression.

Wed May 23 00:00:00 EDT 2018

The PDGFRβ/ERK1/2 pathway regulates CDCP1 expression in triple-negative breast cancer.

BMC cancer

Forte L,Turdo F,Ghirelli C,Aiello P,Casalini P,Iorio MV,D'Ippolito E,Gasparini P,Agresti R,Belmonte B,Sozzi G,Sfondrini L,Tagliabue E,Campiglio M,Bianchi F

PA5-17245 was used in Immunohistochemistry to study the mechanisms driving CDCP1 over-expression.

Wed May 23 00:00:00 EDT 2018

Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation.

American journal of physiology. Lung cellular and molecular physiology

Noskovičová N,Heinzelmann K,Burgstaller G,Behr J,Eickelberg O

PA5-17245 was used in Immunocytochemistry-immunoflourescence to show that loss of CDCP1 contributes to fibroblast to myofibroblast differentiation via a potential negative feedback loop between CDCP1 expression and TGF-Β1 stimulation.

Tue May 01 00:00:00 EDT 2018

CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers.

Oncotarget

Turdo F,Bianchi F,Gasparini P,Sandri M,Sasso M,De Cecco L,Forte L,Casalini P,Aiello P,Sfondrini L,Agresti R,Carcangiu ML,Plantamura I,Sozzi G,Tagliabue E,Campiglio M

PA517245 was used in immunohistochemistry - paraffin section to assess the use of CDCP1 expression as a biomarker for highly aggressive triple-negative breast cancer

Tue Oct 25 00:00:00 EDT 2016

CDCP1 is a novel marker of the most aggressive human triple-negative breast cancers.

Oncotarget

Turdo F,Bianchi F,Gasparini P,Sandri M,Sasso M,De Cecco L,Forte L,Casalini P,Aiello P,Sfondrini L,Agresti R,Carcangiu ML,Plantamura I,Sozzi G,Tagliabue E,Campiglio M

PA517245 was used in immunohistochemistry - paraffin section to assess the use of CDCP1 expression as a biomarker for highly aggressive triple-negative breast cancer

Tue Oct 25 00:00:00 EDT 2016

生物信息学

蛋白别名: CD318; CUB domain-containing protein 1; gp140; Membrane glycoprotein gp140; SIMA135; Subtractive immunization M plus HEp3-associated 135 kDa protein; Transmembrane and associated with src kinases

基因别名: CD318; CDCP1; SIMA135; TRASK; UNQ2486/PRO5773

UniProt ID: (Human) Q9H5V8

Entrez Gene ID: (Human) 64866

参与通路

protein binding

CDCP1 Polyclonal Antibody

产品信息

PA5-17245

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

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