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Proteintech
CDK5RAP2 Polyclonal Antibody
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产品信息
31702-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CDK5RAP2 fusion protein Ag36245
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MQLFSEIHNL QNKFRDLSPP RYDSLVQSQA RELSLQRQQI KDGHGICVIS RQHMNTMIKA FEELLQASDV DYCVAEGFQE QLNQCAELLE KLEKLFLNGK SVGVEMNTQN ELMERIEEDN LTYQHLLPES PEPSASHALS DYETSEKSFF SRDQKQDNET EKTSVMVNSF SQDLLMEHIQ EIRTLRKRLE ESIKTNEKLR KQLERQGSEF VQGSTSIFAS GSELHSSLTS EIHFLRKQNQ ALNAMLIKGS RDKQKENDKL RESLSRKTVS LEHLQREYAS VKEENERLQK EGSEKERHNQ QLIQEVRCSG QELSRVQEEL KLRQQLLSQN DKLLQSLRVE LKAYEKLDEE H
靶标信息
CDK5RAP2 is a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein is localized to the centrosome and Golgi complex and interacts with CDK5R1 and pericentrin (PCNT). CDK5RAP2 plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDK5 activator-binding protein C48; CDK5 regulatory subunit-associated protein 2; centrosomal protein 215 kDa; Centrosome-associated protein 215; centrosomin
基因别名: C48; CDK5RAP2; CEP215; KIAA1633; MCPH3
UniProt ID: (Human) Q96SN8
Entrez Gene ID: (Human) 55755
G2/M transition of mitotic cell cycle
establishment of mitotic spindle orientation
microtubule cytoskeleton organization
microtubule bundle formation
chromosome segregation
centriole replication
brain development
neurogenesis
microtubule organizing center organization
regulation of neuron differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
negative regulation of centriole replication
centrosome organization
regulation of spindle checkpoint
