Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1-2 µg/mL | - |
免疫细胞化学 (ICC/IF) |
Assay-dependent | 查看1篇已发表文章 1篇已发表文章 |
免疫沉淀 (IP) |
10 µg/mg of lysate | - |
染色质免疫沉淀 实验 (ChIP) |
1-3 µL | 查看1篇已发表文章 1篇已发表文章 |
in situ PLA (PLA) |
- | 查看1篇已发表文章 1篇已发表文章 |
产品规格 | |
---|---|
种属反应 |
Human, Mouse, Rat |
已发表种属 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide: C-SQQPPQYSHQTHRY, corresponding to amino acids 451-464 of Human Cdk8. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.2 mg/mL |
纯化类型 |
Protein A |
保存液 |
10mM PBS, pH 7.4, with 0.2% BSA |
内含物 |
0.09% sodium azide |
保存条件 |
4° C, do not freeze |
RRID |
AB_2291488 |
Recommended positive controls: HT29 cells.
A family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. The p54/Cdk 8 interacts exclusively with Cyclin C. The Cdk 8 Cyclin C complex activates the kinase. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CDK8 protein kinase; Cell division protein kinase 8; Cyclin-dependent kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35
基因别名: CDK8; K35; RGD1560888
UniProt ID: (Human) P49336, (Mouse) Q8R3L8
Entrez Gene ID: (Human) 1024, (Mouse) 264064, (Rat) 498140