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Invitrogen
CDNF Polyclonal Antibody
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CDNF Antibody (PA5-77542) in IHC (F)
Immunohistochemistry analysis of CDNF in immersion-fixed, free floating mouse brain. A) Samples were probed with CDNF polyclonal antibody (Product # PA5-77542) using a dilution of 1:300 (green), and incubated with tyrosine hydroxylase and DAPI. B) Staining of substantia nigra. C) Merged images.
产品信息
PA5-77542
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide (C)EKTLDLASVDLRK, corresponding to amino acid residues 129-141 of human CDNF
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
靶标信息
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6 OHDA) induced degeneration of dopaminergic neurons in a rat model of Parkinsons disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinsons disease. At least two isoforms of CDNF are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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