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Agrisera
CDPK/Calcium-dependent protein kinase isoforms (1, 2, 3, 4, 7, 8, 10, 11, 14, 20, 25, 30, 32) Polyclonal Antibody
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产品信息
AS13-2754
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide conserved in isoform 1,2,3,4,7,8,10,11,14,20,25,30,32 of Arabidopsis thaliana CDPK kinases.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Hordeum vulgare, Populus sp., Triticum aestivum
靶标信息
CDPK genes encode calcium-dependent protein kinases that function as intracellular Ca2+ sensors and effectors, typically localized in the cytosol and at membranes via variable N-terminal segments that can confer targeting and dynamic compartment association. CDPK proteins have a conserved modular architecture consisting of an N-terminal variable region followed by a serine/threonine kinase catalytic domain, an autoinhibitory junction segment, and a C-terminal calmodulin-like regulatory domain containing EF-hand Ca2+-binding motifs; in the absence of Ca2+, the junction acts as a pseudosubstrate to maintain an autoinhibited conformation, while Ca2+ binding to the EF hands triggers conformational rearrangement of the regulatory domain to relieve inhibition and activate kinase activity. In apicomplexan parasites, including Plasmodium falciparum, CDPK1 exemplifies this mechanism and is required for key steps in the blood-stage cycle, where Ca2+-dependent activation of the kinase promotes secretion-linked invasion processes and regulates phosphorylation networks important for erythrocyte invasion and parasite development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcium-dependent protein kinase; CDPK; CPK
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