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Invitrogen
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1-3 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Goat / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide sequence (ARLAHQTRAEEGL) corresponding to the C-terminus amino acids of CDT1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.5 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
TBS, pH 7.3, with 0.5% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_10985522 |
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CDT1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP
基因别名: CDT1; DUP; RIS2
UniProt ID: (Human) Q9H211
Entrez Gene ID: (Human) 81620
分子生物学功能:
DNA metabolism protein
