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Invitrogen
CDX1 Polyclonal Antibody
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CDX1 Antibody (PA5-109508) in WB
Western blot analysis of CDX1 in extracts of various cell lines. Samples were incubated with CDX1 Polyclonal antibody (Product # PA5-109508) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-109508
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 136-265 of human CDX1 (NP_001795.2).
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MRRSVAAGGG GGSGKTRTKD KYRVVYTDHQ RLELEKEFHY SRYITIRRKS ELAANLGLTE RQVKIWFQNR RAKERKVNKK KQQQQQPPQP PMAHDITATP AGPSLGGLCP SNTSLLATSS PMPVKEEFLP
靶标信息
CDX1, or caudal type homeobox 1, is a gene encoding a homeodomain transcription factor that plays a significant role in the development and differentiation of intestinal epithelial cells. CDX1 is expressed in the intestinal crypts, where it is integral to the Wnt/B-catenin signaling pathway, crucial for cell proliferation. Interestingly, while CDX1 expression is initially active, its expression is often silenced as colon cancer progresses in humans, suggesting a complex role in tumor biology. The CDX1 protein functions as a transcriptional regulator that influences proliferation and differentiation, expressing early during intestinal development. In mice, it is involved in the development of the posterior embryo and is associated with abnormal differentiation in metaplastic and neoplastic tissues, providing insight into intestinal-type gastric adenocarcinoma progression. CDX1 is related to other vertebrate Cdx genes such as Cdx2 and Cdx4, which are homologues of the Drosophila caudal gene and are also implicated in embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caudal type homeo box 1; caudal type homeo box transcription factor 1; caudal type homeobox transcription factor 1; Caudal-type homeobox protein 1; caudal-type homeobox protein CDX1; Homeobox protein CDX-1
基因别名: Cdx; Cdx-1; CDX1
UniProt ID: (Human) P47902, (Mouse) P18111
Entrez Gene ID: (Human) 1044, (Mouse) 12590
transcription from RNA polymerase II promoter
organ morphogenesis
anterior/posterior axis specification
regulation of somitogenesis
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
bone morphogenesis
regulation of transcription, DNA-templated
multicellular organism development
pattern specification process
anterior/posterior pattern specification
