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Invitrogen
CEACAM1 Recombinant Superclonal Antibody (10HCLC)
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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CEACAM1 Antibody (711088) in WB
Western blot was performed using Anti-CEACAM1 Antibody (10HCLC), ABfinity Rabbit Oligoclonal (Product # 711088) and a 150kDa band corresponding to CEACAM1 was observed across cell lines tested. Whole cell extracts (30 µg lysate) of Hep G2 (Lane 1), COLO 205 (Lane 2), PC-3 (Lane 3) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the prima... View More
产品信息
711088
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
10HCLC
抗原
Protein corresponding to Human CEACAM (aa 305-429)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2633116
产品详细信息
This antibody is predicted to react with Monkey, Horse and Cat
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
CEACAM1 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a; CD66a antigen
基因别名: BGP; BGP1; BGPI; CEACAM1
UniProt ID: (Human) P13688
Entrez Gene ID: (Human) 634
angiogenesis
regulation of cell growth
blood vessel development
negative regulation of T cell mediated cytotoxicity
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
negative regulation of protein kinase activity
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
integrin-mediated signaling pathway
regulation of endothelial cell migration
regulation of phosphatidylinositol 3-kinase signaling
bile acid and bile salt transport
cell migration
regulation of cell migration
negative regulation of granulocyte differentiation
negative regulation of interleukin-1 production
cellular response to insulin stimulus
common myeloid progenitor cell proliferation
insulin receptor internalization
granulocyte colony-stimulating factor signaling pathway
regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of cytotoxic T cell degranulation
wound healing, spreading of cells
regulation of endothelial cell differentiation
negative regulation of fatty acid biosynthetic process
negative regulation of T cell receptor signaling pathway
leukocyte migration
negative regulation of lipid biosynthetic process
regulation of blood vessel remodeling
regulation of ERK1 and ERK2 cascade
negative regulation of platelet aggregation
cell-cell adhesion
insulin catabolic process
regulation of homophilic cell adhesion
regulation of sprouting angiogenesis
negative regulation of hepatocyte proliferation
positive regulation of vasculogenesis
