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Bethyl Laboratories

CEACAM1/CEACAM5 Recombinant Rabbit Monoclonal Antibody (BLR032F)

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CEACAM1/CEACAM5 Recombinant Rabbit Monoclonal Antibody (BLR032F)

产品信息

A700-032

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-

流式细胞分析 (Flow)

0.5 µL per 1 x 10^6 cells
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

BLR032F

抗原

Recombinant protein representing the extracellular domain of human CEACAM1 (residues 35-433).
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

50 µg/mL

规格

5 µg

纯化类型

Antigen affinity chromatography

保存液

BBS, pH 8.2, with 0.1% BSA

内含物

0.09% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

靶标信息

Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: antigen CD66; BGP; biliary glycoprotein adhesion molecule; biliary glycoprotein I precursor; carcinoembronyic antigen; carcinoembryonic antigen; carcinoembryonic antigen precursor; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen related cell adhesion molecule 5; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD66a antigen; CEACAM1-3S; meconium antigen 100; pan CEACAM; sCD66e; soluble CD66e

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基因别名: BGP; BGP1; BGPI; CD66e; CEA

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UniProt ID: (Human) P13688, (Human) P06731

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Entrez Gene ID: (Human) 634, (Human) 1048

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功能
actin binding protein binding calmodulin binding bile acid transmembrane transporter activity kinase binding protein phosphatase binding filamin binding identical protein binding protein homodimerization activity protein dimerization activity protein tyrosine kinase binding GPI anchor binding
参与通路
angiogenesis regulation of cell growth blood vessel development negative regulation of T cell mediated cytotoxicity regulation of immune system process negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of protein kinase activity cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules signal transduction integrin-mediated signaling pathway regulation of endothelial cell migration bile acid and bile salt transport cell migration regulation of cell migration negative regulation of granulocyte differentiation negative regulation of interleukin-1 production cellular response to insulin stimulus common myeloid progenitor cell proliferation insulin receptor internalization granulocyte colony-stimulating factor signaling pathway regulation of epidermal growth factor receptor signaling pathway negative regulation of vascular permeability negative regulation of cytotoxic T cell degranulation wound healing, spreading of cells regulation of endothelial cell differentiation negative regulation of fatty acid biosynthetic process negative regulation of T cell receptor signaling pathway negative regulation of lipid biosynthetic process regulation of protein kinase B signaling regulation of blood vessel remodeling regulation of ERK1 and ERK2 cascade negative regulation of platelet aggregation cell-cell adhesion insulin catabolic process regulation of homophilic cell adhesion regulation of sprouting angiogenesis negative regulation of hepatocyte proliferation positive regulation of vasculogenesis heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules negative regulation of myotube differentiation homotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of anoikis
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