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产品信息
PA5-50591
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:25-1:100 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to a region derived from internal residues of human cadherin, EGF LAG seven-pass G-type receptor 2 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.6 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636044 |
产品详细信息
The antibody detects endogenous levels of total CELSR2 protein.
靶标信息
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adhesion G protein-coupled receptor C2; cadherin EGF LAG seven-pas G-type receptor 2; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); EGF-like protein 2; EGF-like-domain, multiple 2; epidermal growth factor-like 2; Epidermal growth factor-like protein 2; Flamingo homolog 3; flamingo-like protein celsr2; Flamingo1; FLJ34118; FLJ42737; FLJ45143; FLJ45845; Multiple EGF-like domains protein 3; multiple epidermal growth factor-like domains 3; Multiple epidermal growth factor-like domains protein 3; seven-pass transmembrane cadherin
基因别名: ADGRC2; CDHF10; CELSR2; EGFL2; Flamingo1; KIAA0279; MEGF3
UniProt ID: (Human) Q9HCU4
Entrez Gene ID: (Human) 1952, (Rat) 83465
分子生物学功能:
cadherin
regulation of transcription, DNA-templated
homophilic cell adhesion via plasma membrane adhesion molecules
G-protein coupled receptor signaling pathway
spermatogenesis
Wnt signaling pathway
neural plate anterior/posterior regionalization
regulation of cell-cell adhesion
dendrite morphogenesis
Wnt signaling pathway, planar cell polarity pathway
neuron migration
cilium movement
ventricular system development
regulation of protein localization
cerebrospinal fluid secretion
cilium assembly
