Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
CENPE Recombinant Rabbit Monoclonal Antibody (K01_1P48)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA563816
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_1P48
抗原
A synthetic peptide of human CENPE.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 0.05% BSA, 150mM NaCl, 40% glycerol
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
14-3-3 sigma (stratifin, SFN, epithelial cell marker protein 1) is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known mammalian 14-3-3 isoforms epsilon, beta, zeta, gamma, theta, tau and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 sigmais the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to g-irradiation and other DNA-damaging agents. 14-3-3 sigmais a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of human 14-3-3 sigma are produced by alternative splicing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CENP-E; Centromere autoantigen E (312kD); Centromere protein E; centromere protein E, 312kDa; Centromere-associated protein E; kinesin family member 10; Kinesin-7; Kinesin-related protein CENPE; protein phosphatase 1, regulatory subunit 61
基因别名: CENP-E; CENPE; KIF10; MCPH13; PPP1R61
UniProt ID: (Human) Q02224
Entrez Gene ID: (Human) 1062
mitotic cell cycle
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
chromosome segregation
sister chromatid cohesion
mitotic chromosome movement towards spindle pole
mitotic metaphase plate congression
multicellular organism development
antigen processing and presentation of exogenous peptide antigen via MHC class II
regulation of mitotic metaphase/anaphase transition
positive regulation of protein kinase activity
cell division
attachment of mitotic spindle microtubules to kinetochore
kinetochore assembly
