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Invitrogen
CENPO Polyclonal Antibody
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CENPO Antibody (PA5-100722) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded CENPO in mouse liver tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with CENPO polyclonal antibody (Product # PA5-100722) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-100722
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CENPO(Accession Q9BU64), corresponding to amino acid residues Y183-F233.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CENPO.
靶标信息
Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CENP-O; Centromere protein O; centromeric protein O; Interphase centromere complex protein 36
基因别名: 2810429O05Rik; 8430427C03Rik; CENP-O; CENPO; D12Ertd482e; ICEN-36; ICEN36; MCM21R
UniProt ID: (Human) Q9BU64, (Mouse) Q8K015
Entrez Gene ID: (Human) 79172, (Mouse) 52504
