Invitrogen

CETP Polyclonal Antibody

Name: CETP Polyclonal Antibody
Brand: Invitrogen
SKU: PA1-050

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2个已发表图片

1 篇参考文献

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说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

图: 1 / 5

CETP Antibody (PA1-050) in WB

Western blot detection of CETP from rat liver extract using Product # PA1-050.

Product Image Gallery

CETP Antibody — CETP contributes to cancer cell growth and survival and is upregulated in breast cancer patients (A) CETP gene silencing by siRNA and western blot analysis of CETP protein expression in CETP siRNA cells. (B) Effect of CETP mRNA silencing on growth of MCF-7 cells as measured by cell counting over a period of six days. (C) Comparison of cholesterol levels in the MCF-7 control (ctrl) siRNA and CETP knockout cells. Data shown are the mean ± SD of quadruplicate wells/condition in three independent experiments (n = 3) (P ≤ 0.05, t-test). (D) The effect of 10 µM PL or AP treatment on MOMP; (E) Capase-3/7 activity (10, 25 and 50 µM Tamoxifen was used as a positive control); and (F) apoptosis in MCF-7 ctrl siRNA and CETP siRNA knockout cells. Data shown are representative of the mean ± SD of quadruplicate wells/condition in at least two independent experiments (n=2) (*P ≤ 0.05, t-test). {KD}

Immunogen image

Immunogen Image CETP Polyclonal Antibody

产品信息

PA1-050

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2 µg/mL

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_325072

产品详细信息

PA1-050 detects cholesteryl ester transfer protein (CETP) from human tissues.

PA1-050 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~70 kDa band from human liver extracts representing CETP.

The PA1-050 immunogen is a synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein.This peptide (Cat. # PEP-209) is available for use in neutralization and control experiments.

靶标信息

It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: BPI fold containing family F; Cholesteryl ester transfer protein; cholesteryl ester transfer protein plasma; cholesteryl ester transfer protein, plasma; Lipid transfer protein I

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基因别名: BPIFF; CETP; HDLCQ10

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UniProt ID: (Human) P11597

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Entrez Gene ID: (Human) 1071

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功能

lipid transporter activity phospholipid transporter activity lipid binding cholesterol binding cholesterol transporter activity triglyceride binding phosphatidylcholine binding

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