Invitrogen

CHMP1A Polyclonal Antibody

产品信息

PA5-50379

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:500-1:2,000	-
免疫组化（石蜡） (IHC (P))	1:50-1:200	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Full length fusion protein of Human CHMP1A 查看免疫原
偶联物	Unconjugated
形式	Liquid
浓度	2.4 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2635832

产品详细信息

The antibody detects endogenous levels of total CHMP1A protein.

靶标信息

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I, -II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: charged multivesicular body protein 1/chromatin modifying protein 1; Charged multivesicular body protein 1a; CHMP1a; chromatin modifying protein 1A; Chromatin-modifying protein 1a; hVps46-1; procollagen (type III) N-endopeptidase; protease, metallo, 1, 33kD; Vacuolar protein sorting-associated protein 46-1; Vps46-1

基因别名: 2900018H07Rik; CHMP1; CHMP1A; KIAA0047; PCH8; PCOLN3; PRSM1; VPS46-1; VPS46A

UniProt ID: (Human) Q9HD42, (Mouse) Q921W0

Entrez Gene ID: (Human) 5119, (Mouse) 234852

分子生物学功能: membrane traffic protein C2H2 zinc finger transcription factor