Invitrogen

CHMP4B Polyclonal Antibody

产品信息

PA5-50380

应用	建议稀释比	已发表文章
免疫组化（石蜡） (IHC (P))	1:50-1:200	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Fusion protein corresponding to a region derived from internal residues of human charged multivesicular body protein 4B
偶联物	Unconjugated
形式	Liquid
浓度	1.7 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2635833

产品详细信息

The antibody detects endogenous levels of total CHMP4B protein.

靶标信息

CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Charged multivesicular body protein 4b; CHMP4b; chromatin modifying protein 4B; Chromatin-modifying protein 4b; hSnf7-2; hVps32-2; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; SNF7-2; Vacuolar protein sorting-associated protein 32-2; vacuolar protein-sorting-associated protein 32-2; Vps32-2

基因别名: 2010012F05Rik; C20orf178; C76846; CHMP4A; CHMP4B; CTPP3; CTRCT31; dJ553F4.4; SHAX1; SNF7; SNF7-2; Vps32-2; VPS32B

UniProt ID: (Human) Q9H444, (Mouse) Q9D8B3

Entrez Gene ID: (Human) 128866, (Mouse) 75608

分子生物学功能: membrane traffic protein