This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. 查看细节
Immunogen sequence: EQEELDKNLL EISGPETVPL PNVPSIALPS KPAKKKEEED DDMKELENWA GSV
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
蛋白别名: Charged multivesicular body protein 4b; CHMP4b; chromatin modifying protein 4B; Chromatin-modifying protein 4b; hSnf7-2; hVps32-2; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; SNF7-2; Vacuolar protein sorting-associated protein 32-2; vacuolar protein-sorting-associated protein 32-2; Vps32-2
基因别名: C20orf178; CHMP4A; CHMP4B; CTPP3; CTRCT31; dJ553F4.4; SHAX1; SNF7; SNF7-2; Vps32-2; VPS32B
UniProt ID: (Human) Q9H444
Entrez Gene ID: (Human) 128866
分子生物学功能: membrane traffic protein