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Invitrogen
CHRM2 Polyclonal Antibody
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CHRM2 Antibody (PA5-111845) in IHC (F)
Immunohistochemistry analysis of CHRM2 in frozen mouse parieto-temporal cortex sections tissue sections using CHRM2 Antibody (Product # PA5-111845) at a dilution of 1:100. mAChR M2 staining (red) was dense in layer IV, with fibers climbing to layers II-III. Kir3.2 K+ channel staining (green) was dense in layers IV and I. Overlapping expression of Kir3.2 channel and mAChR M2 is seen in cortical layers.
产品信息
PA5-111845
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GST fusion protein corresponding to amino acid residues 225-356 of human M2
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
GST fusion protein sequence is: VANQDPVSPS LVQGRIVKPN NNNMPSSDD GLEHNKIQNG KAPRDPVTEN CVQGEEKESS NDSTSV SAV ASNMRDDEIT QDENTVSTSL GHSKDENSKQ TCIRIGTKTP KS DSCTPTN TTVEVVGSSG QNGDE
Homology: Chimpanzee, gorilla amino acid residues identical; orangutan - 130/132 amino acid residues identical; pig - 122/132 amino acid residues identical; rat - 118/132 amino acid residues identical; mouse - 117/132 amino acid residues identical; dog - 122/132 amino acid residues identical.
靶标信息
Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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