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Alomone Labs, LTD
CHRM5 (extracellular) Polyclonal Antibody
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CHRM5 (extracellular) Antibody (AMR-005-200UL) in WB
Western blot analysis of rat lung (lanes 1 and 5) and brain (lanes 2 and 6) membranes, human A-875 melanoma (lanes 3 and 7) and human MALM-3M malignant melanoma (lanes 4 and 8) cell lysates: - 1-4. Anti-CHRM5 (extracellular) Antibody (#AMR-005), (1:200).5-8. Anti-CHRM5 (extracellular) Antibody , preincubated with CHRM5 (extracellular) Blocking Peptide (#BLP-MR005).
产品信息
AMR-005-200UL
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HNATTVNGTPVNHQPLER, corresponding to amino acid residues 7-24 of human M5 muscarinic receptor, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 5; cholinergic receptor; cholinergic receptor, muscarinic 5; Muscarinic acetylcholine receptor M5
基因别名: Chrm-5; CHRM5; HM5
UniProt ID: (Human) P08912, (Rat) P08911
Entrez Gene ID: (Human) 1133, (Rat) 53949
gastric acid secretion
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
cell proliferation
dopamine transport
transmission of nerve impulse
regulation of phosphatidylinositol dephosphorylation
