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Invitrogen
CIS Polyclonal Antibody
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CIS Antibody (PA5-117039) in WB
Western blot analysis of CIS in extracts of various cell lines. Samples were incubated with CIS Polyclonal antibody (Product # PA5-117039) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.
产品信息
PA5-117039
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human CISH (NP_6595081)
偶联物
形式
Liquid
浓度
0.53 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Mouse liver
Immunogen sequence: MVLCVQGPRP LLAVERTGQR PLWAPSLELP KPVMQPLPAG AFLEEVAEGT PAQTESEPKV LDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI LAFPDVVSLV QHYVASCTAD TRSDSPDPAP TPALPMPKED APSDPALPAP PPATAVHLKL VQPFVRRSSA RSLQHLCRLV INRLVADVDC LPLPRRMADY LRQYPFQ
靶标信息
CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CIS; CIS-1; cytokine inducible SH2-containing protein 1; cytokine-inducible SH2 protein; Cytokine-inducible SH2-containing protein; SOCS; Suppressor of cytokine signaling
基因别名: AI385595; Cis; CIS1; Cish; F17; F23
UniProt ID: (Mouse) Q62225
Entrez Gene ID: (Rat) 83681, (Mouse) 12700
negative regulation of protein kinase activity
protein kinase C-activating G-protein coupled receptor signaling pathway
protein ubiquitination
cytokine-mediated signaling pathway
intracellular signal transduction
regulation of growth
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
negative regulation of signal transduction
