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CIS Antibody (710864) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of THP-1 (Lane1) and THP-1 treated with IL-2 (20 ng/24 hours) (Lane2). The blots were probed with Anti-CIS Recombinant Rabbit Superclonal™ Antibody (Product # 710864, 0.5-1 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A clear 30 kDa band corresponding to CIS was observed in cell line tested. Known quantity of protein samples were electro... View More
产品信息
710864
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
抗原
Peptide corresponding to Human CIS (aa 1-258)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532775
产品详细信息
This antibody is predicted to react with Monkey, Pig, Bovine, Rat and Mouse.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
靶标信息
CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CIS; CIS-1; cytokine inducible SH2-containing protein; cytokine-inducible inhibitor of signaling type 1B; Cytokine-inducible SH2-containing protein; Protein G18; SOCS; Suppressor of cytokine signaling
基因别名: BACTS2; CIS; CIS-1; CISH; G18; SOCS
UniProt ID: (Human) Q9NSE2
Entrez Gene ID: (Human) 1154
regulation of cell growth
negative regulation of protein kinase activity
protein kinase C-activating G-protein coupled receptor signaling pathway
protein ubiquitination
cytokine-mediated signaling pathway
intracellular signal transduction
negative regulation of JAK-STAT cascade
negative regulation of insulin receptor signaling pathway
