This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: VKYWICLALI EPITSPIENI IAIYEKAILA GAQPIEEMRH TIVDILTMKS QEKANLGENM EKSCASKEEV KEVSIEDTGV DVDPEKLEME SKLHRNLLFQ DCEKEQDNKT KDPTH
Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 63%.
Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.
蛋白别名: CKAP2; CTCL tumor antigen se20-10; Cytoskeleton-associated protein 2; Tumor- and microtubule-associated protein; tumor-associated microtubule-associated protein
基因别名: CKAP2; LB1; se20-10; TMAP
UniProt ID: (Human) Q8WWK9
Entrez Gene ID: (Human) 26586