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Immunogen sequence: SRASNSAVP PATVEAFVER DSLHFPHPVM IYANVKQGFY PILNATVTAT VEPETGDPVT LRLLDDGAGA DVIKNDGIYS RYFFSFAANG RYSLKVHVNH SPSISTPAHS IPGSHAMYVP GYTANGNIQM NAPRKSVGRN EEERKWGFSR VSSGGSFSVL GVPAGPHPDV FPPCKIIDLE AVKVEEELTL SWTAPGEDFD QGQATSYEIR MSKSLQNIQD DFNNAILVNT SKRNPQQAGI REIFTFSPQI STNGPEHQPN GETHESHRIY VAIRAMDRNS LQSAVSNIAQ APLFIPPNSD PVPARDYL (595-901 aa encoded by BC041096)
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CaCC-3; Calcium-activated chloride channel family member 2; Calcium-activated chloride channel family member 5; Calcium-activated chloride channel protein 3; Calcium-activated chloride channel regulator 2; calcium-activated chloride channel-2; chloride channel calcium activated 5; chloride channel regulator 2; chloride channel, calcium activated, family member 2; CLCA family member 2, chloride channel regulator; FLJ97885; hCaCC-3; hCLCA2; mCLCA5
基因别名: 4732440A06; AI586120; CACC; CaCC-3; CACC3; CLCA2; Clca5; CLCRG2
UniProt ID: (Human) Q9UQC9, (Mouse) Q8BG22
Entrez Gene ID: (Human) 9635, (Mouse) 229933
分子生物学功能: ion channel