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Invitrogen
CLEC5A Polyclonal Antibody
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CLEC5A Antibody (PA5-47173) in ICC/IF
Immunocytochemistry analysis of CLEC5A in immersion fixed RAW 264.7 mouse monocyte/macrophage cell line. Samples were incubated in CLEC5A polyclonal antibody (Product # PA5-47173) using a dilution of 1.7 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI(blue). Specific staining was localized to plasma membrane.
产品信息
PA5-47173
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse MDL-1/CLEC5A Tyr26-Lys190
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human MDL-1/CLEC5A is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin domain family 5 member A; C-type lectin superfamily member 5; MDL-1; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1; type II transmembrane protein MDL-1
基因别名: Clec5a; Clecsf5; Ly100; MDL-1; Mdl1
UniProt ID: (Mouse) Q9R007
Entrez Gene ID: (Mouse) 23845
