Invitrogen

CLIC5 Monoclonal Antibody (CLIC5-02), Alexa Fluor™ 647

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CLIC5 Antibody (MA562365) in Flow

Flow cytometry (intracellular staining) of CLIC5 in human peripheral whole blood. Samples were stained with CLIC5 monoclonal antibody (Product # MA562365) using a dilution of 5 µg/mL. Separation of NALM-6 cells (red-filled) from human neutrophil granulocytes (black-dashed).

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产品信息

MA562365

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

流式细胞分析 (Flow)

1-5 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

CLIC5-02

抗原

KLH-conjugated peptide corresponding to the amino acids 160-173 of human CLIC5a (Cys-Ile-Asp-Ala-Asn-Thr-Ser-Asp-Lys-Gly-Ser-Arg-Arg coupled with KLH).

查看免疫原

偶联物

Alexa Fluor™ 647 Alexa Fluor™ 647 Alexa Fluor™ 647

激发/发射光谱

650/671 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Size-exclusion chromatography

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

15mM sodium azide

保存条件

4°C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Clic5 encodes a protein that is required for normal hearing and is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Clic5 can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Clic5 may play a role in the regulation of transepithelial ion absorption and secretion, and is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. The Clic5 gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The protein encoded by Clic5 associates with actin-based cytoskeletal structures and may also play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for the Clic5 gene. Diseases associated with CLIC5 include Deafness, Autosomal Recessive 103 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb.

仅用于科研。不用于诊断过程。未经明确授权不得转售。