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Immunogen sequence: SFLKSFPPPG PAEGLLRQQP DTEAVLNGKG LGTGTLYIAE SRLSWLDGSG LGFSLEYPTI SLHALSRDRS DCLGEHLYVM VNAKFEEESK EPVADEE
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.
Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ARPC1A; chloride channel regulatory protein; Chloride channel, nucleotide sensitive 1A; chloride channel, nucleotide-sensitive, 1A; Chloride conductance regulatory protein ICln; Chloride ion current inducer protein; ClCI; I(Cln); Methylosome subunit pICln; Reticulocyte pICln; reticulocyte protein ICln; SOP2L
基因别名: CLCI; CLNS1A; CLNS1B; ICLN
UniProt ID: (Human) P54105
Entrez Gene ID: (Human) 1207
分子生物学功能: transporter